Home
Issues
Aim & Scope
Open Access
Editorial Board
Indexing
Why publish with us
Contact us
Instructions to Authors (PDF)
Manuscript Types
Manuscript Formatting
How to submit
Preprints
Authorship & COI
Principles of Transparency Checklist
Data Policies
Publication Ethics and Publication Malpractice Statement
ORIGINAL STUDY
The impact of anaemia, leukocytosis and thrombocytosis on survival in patients with lung cancer resection
1
Clinic of Pneumonology, Department of Oncology, Clinical Centre of Serbia, Belgrade, Serbia
2
Department of Pneumonology and Thoracic pathology, Service for Pathology, Clinical Centre of Serbia, Belgrade, Serbia
3
Department of Pneumonology, Medical School, Democritus University of Thrace and University Hospital of Alexandroupolis, Greece
Corresponding author
Tatjana N. Adžić
Clinic for Pneumonology, Department of Oncology, Clinical Centre of Serbia, Belgrade, Serbia
Clinic for Pneumonology, Department of Oncology, Clinical Centre of Serbia, Belgrade, Serbia
Pneumon 2011;24(1):35-39
KEYWORDS
ABSTRACT
Introduction:
Previous studies have reported that preoperative leukocytosis, anaemia and thrombocytosis are related to the prognosis of non-small cell lung cancer (NSCLC). The aim of this study was to determine impact of these haematological parameters in patients of different ages with NSCLC.
Material and Methods:
Among 2,050 patients who underwent lung resection for NSCLC in the 5-year period 2002-2007, 200 were reviewed, of whom 93 were aged above 70 years.
Results:
The frequency of preoperative leukocytosis, anaemia and thrombocytosis was 21% (42/200), 32.5% (65/200), 16.5% (33/200), respectively. The 5-year survival of the patients with and without leukocytosis, anaemia and thrombocytosis was 26.5% vs 27.4%, 28.9% vs 27.2% and 31.7% vs 26.6%, respectively. No significant difference was observed in the 5-year survival according to either the presence or absence of preoperative leukocytosis, anaemia and thrombocytosis, or the age group, <70 years and ≥70 years. Significant difference was found in the haemoglobin (Hb) level between the different age groups, 3 (p=0.0025), 6 (p<0.001) and 12 (p=0.033) months postoperatively. Leukocytosis, anaemia and thrombocytosis were frequently found in earlier stages of NSCLC and in connection with extended types of surgical resection.
Conclusions:
Preoperative anaemia, leukocytosis and thrombocytosis are not related with patient survival after lung resection for NSCLC, although the measurement is inexpensive and routinely used. An abnormal blood cell count in patients with cancer is not always a tumour-related phenomenon.
Previous studies have reported that preoperative leukocytosis, anaemia and thrombocytosis are related to the prognosis of non-small cell lung cancer (NSCLC). The aim of this study was to determine impact of these haematological parameters in patients of different ages with NSCLC.
Material and Methods:
Among 2,050 patients who underwent lung resection for NSCLC in the 5-year period 2002-2007, 200 were reviewed, of whom 93 were aged above 70 years.
Results:
The frequency of preoperative leukocytosis, anaemia and thrombocytosis was 21% (42/200), 32.5% (65/200), 16.5% (33/200), respectively. The 5-year survival of the patients with and without leukocytosis, anaemia and thrombocytosis was 26.5% vs 27.4%, 28.9% vs 27.2% and 31.7% vs 26.6%, respectively. No significant difference was observed in the 5-year survival according to either the presence or absence of preoperative leukocytosis, anaemia and thrombocytosis, or the age group, <70 years and ≥70 years. Significant difference was found in the haemoglobin (Hb) level between the different age groups, 3 (p=0.0025), 6 (p<0.001) and 12 (p=0.033) months postoperatively. Leukocytosis, anaemia and thrombocytosis were frequently found in earlier stages of NSCLC and in connection with extended types of surgical resection.
Conclusions:
Preoperative anaemia, leukocytosis and thrombocytosis are not related with patient survival after lung resection for NSCLC, although the measurement is inexpensive and routinely used. An abnormal blood cell count in patients with cancer is not always a tumour-related phenomenon.
REFERENCES (20)
1.
Parkin DM, Bray F, Ferlay J, Pisani P.Global cancer statistics 2002; CA Cancer J Clin 2005;55:74-108.
2.
Yang P, Allen S, Aubry C, et al. Clinical features of 5628 primary lung cancer petients: experience at Mayo Clinic from 1997 to 2003. Chest 2005;128:452-62.
3.
Paesmans M, Sculier P, Libert P, et al. Prognostic factors for survival in advanced non-small cell lung cancer: univariate and multivariate analyses including recursive partitioning and amalgamation algorithms in 1052 patients. The European Lung Cancer Working Party. J Clin Oncol 1995;13:1221-1230.
4.
Tomita M, Shimizu T, Hara M, et al. Preoperative leukocytosis, anemia and thrombocytosis are associated with poor survival in non-small cell lung cancer. Antican Research 2009;29:2687- 2690.
5.
Travis WD, Brambilla E, Muller-Hermelink HK, Harris CC editors. World Health Organisation classification of tumors. Pathology and genetics of tumors of the lung, pleura, thymus and heart. Lyon: IARC;2004.
6.
Goldstraw P. Staging handbook in Thoracic Oncology. An International Association for the study of lung cancer. IASCLC; 2009.
7.
Aoe A, Hiraki A, Maeda T, et al. Serum haemoglobin level determined at the first presentation is a poor prognostic indicator in patients with lung cancer. Intern Med 2005;44:800-804.
8.
Kasuga I, Makino S, Kiyokawa H, et al. Tumor-related leukocytosis is linked with poor prognosis in patients with lung carcinoma. Cancer 2001;92:2399-2405.
9.
Ferrigno D, Buccheri G. Hematologic counts and clinical correlates in 1201 newly diagnosed lung cancer patients. Monaldi Arch Chest Dis 2003;59:193-198.
10.
Langendijk H, De Jong J, Wanders R, et al. The importance of pretreatment haemoglobin level in inoperable non-small cell lung carcinoma treated with radical radiotherapy. Radiother Oncol 2003;67:321-325.
11.
Tibaldi C,Vasile E, Bernandini I, et al. Baselline elevated leukocyte count in peripheral non-small cell lung cancer: a prognostic model. J Cancer Res Clin Oncol 2008;134:1143-1149.
12.
Maione P, Rossi A, Di Maio M, Gridelli C. Tumor related leukocytosis and chemotherapy-induced neutropenia: linked or independent prognostic factors for advanced non-small cell lung cancer. Lung Cancer 2009;66:8-14.
13.
Mandrekar J, Schild E, Hilman L, et al. A prognostic model for advanced stage non small cell lung cancer. Pooled analysis of North Central Cancer Treatment Group trials. Cancer 2006;107:781-792.
14.
Anile M, Venuta F, Diso D, et al. Preoperative anemia does not affect the early postoperative outcome in patients with lung cancer. Minerva Chir 2007;62:431-5.
15.
Garcia Prim M, Gonzales-Barcala J, Moides Rodriguez M, et al. Impact of haemoglobin level on lung cancer survival. Med Clin (Barc) 2008;131:601-4.
16.
Yovino S, Kwok Y, Krasna M, et al. An association between preoperative anemia and decreased survival in early-stage non-small-cell lung cancer patients treated with surgery alone. Int J Radiat Oncol Biol Phys 2005;62:1438-43.
17.
Alexandrakis G, Passam H, Perisinakis K, et al. Serum proniflammatory cytokines and its relationship to clinical parameters in lung cancer patients with reactive thrombocytosis. Respir Med 2002;96:553-558.
18.
Nierodzik L, Karpatin S. Thrombin induces tumor growth, metastasis and angiogenesis. Evidence for a thrombin regulated dormant tumor phenotype. Cancer Cell 2006;10:355-62.
19.
Futami R, Miyashuta M, Namura T, et al. Increased serum vascular endothelial growth factor following major surgical injury. J Nippon Med Sch 2007;74:223-9.
20.
Chamogeorgakis T, Anagnostopoulos C, Kostapanagioton G, et al. Does anemia affect outcome after lobectomy or pneumonectomy in early stage lung cancer patient who have not received neo-adjuvant treatment? Thorac Cardiovasc Surg 2008;56:148-53.
Share
RELATED ARTICLE
| eISSN: | 1791-4914 |
| ISSN: | 1105-848X |
We process personal data collected when visiting the website. The function of obtaining information about users and their behavior is carried out by voluntarily entered information in forms and saving cookies in end devices. Data, including cookies, are used to provide services, improve the user experience and to analyze the traffic in accordance with the Privacy policy. Data are also collected and processed by Google Analytics tool (more).
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
You can change cookies settings in your browser. Restricted use of cookies in the browser configuration may affect some functionalities of the website.
