Lemierre’s syndrome is characterized by acute oropharyngeal infection with secondary septic thrombophlebitis of the internal jugular vein, which is usually complicated with septic metastatic lesions in many organs, but mainly in the lung. Nowadays, the syndrome is a rare complication of the oropharyngeal infections, with generally good prognosis, because of the wide use of antibiotics. The major etiologic factor which is isolated in most cases, is Fusobacterium necrophorum, but rarely the syndrome is caused by other organisms, as Streptococcus species, Peptostreptococcus, Bacteroides, or multiple infecting organisms. We present a case of a 20 years old man, with Lemierre’s syndrome caused by an unusual pathogen, namely Pasteurella multocida. Pneumon 2003, 16(2):209-214.