Endobronchial lipoma is an infrequent benign tumor originating from adipose tissue, most commonly seen in middle-aged men, with a peak incidence between the fifth and sixth decades of life. Usually, the tumor is found in central airways, in lobar or segmental bronchi, mainly located in the right lung and easily detected during bronchoscopy. The lesion may lead to chronic lung destruction due to bronchial obstruction. Bronchoscopic resection with biopsy forceps is both diagnostic and therapeutic method of choice. Lung cancer is the leading cause of mortality worldwide and is diagnosed in advanced stage, due to lack of specific symptoms. Non-small cell lung cancer (NSCLC) accounts for 80-85% of all cases, with adenocarcinoma being the most common histologic subtype. In this article, we present a rare case of co-existence of endobronchial lipoma located in the right lung and adenocarcinoma located in left lung in a 61-year old smoker, without any symptoms.