July - September 2017:
Volume 30, Issue 3

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Pneumon 2017, 30(3):165-174
Lower Respiratory Tract Microbiome
Authors Information
1: Center for Respiratory Failure, Thoracic Diseases General Hospital “Sotiria”, Athens
2: Bioanalytica-Genotype SA, Athens, Greece

Given the fact that the hypothesis of respiratory microbe sterility is being degraded, researchers are currently studying healthy lung microbiota homeostasis as well as its disturbance in case of illness. Taking into consideration the thorough understanding of diseases that gut microbiota studies offered, one cannot but anticipate that respiratory microbiome research would reveal further insight to the pathogenesis of lung disorders but mostly to healthy respiratory physiology. In this article, we review published studies with a view to summarizing important terms and definitions in human microbiome studies, obstacles in lung microbiota research, microbial diversity of lower respiratory tract in health state and major lung diseases, including chronic obstructive pulmonary disease (COPD), asthma, interstitial lung disease (ILD), lung cancer and cystic fibrosis.