January - March 2012:
Volume 25, Issue 1
Click on the image to download the Issue in PDF format.
2025729772
Pneumon 2012, 25(1):114-119
Article Links
- Abstract
- Full article PDF
- Full article HTML
- References
Genetic and environmental influences in obstructive sleep apnoea hypopnoea syndrome
Abstract
SUMMARY. Obstructive sleep apnoea hypopnoea syndrome (OSAHS) is a multifactorial and complex disease. There is a growing body of evidence demonstrating that genetic factors influence the expression of OSAHS. Lack of a consistent definition of the OSAHS phenotype and incomplete understanding of the environmental influences on its expression hinder progress in determination of the OSAHS genotype. In order to elucidate its genetic basis, the OSAHS phenotype can be separated into intermediate phenotypes, based on craniofacial morphology, obesity, susceptibility to sleepiness, ventilatory parameters and upper airway control. Identification of the genetic systems that influence more than one of the intermediate phenotypes may facilitate better understanding of mechanisms underlying OSAHS and lead to formulation of pharmacological interventions. Pneumon 2012, 25(1):114-119. Keywords: Obstructive sleep apnea hypopnea syndrome, genetic factors, phenotype, multifactorial disease
