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January - June 2019: 
Volume 32, Issue 1-2

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Pneumon 2019, 32(1-2):34-42, Case Report
The spectrum of CNS clinical manifestations in patients with small cell lung carcinoma presented through two case reports
Authors Information

1Neurology Department of General Hospital of Serres, Greece
2Pneumonology Department of General Hospital of Serres, Greece

Abstract

Lung cancer is one of the most common neoplasms in the world. In particular, small cell lung carcinoma (SCLC) is one of the most aggressive neoplasms with poor prognosis. Central and peripheral nervous system involvement is very common in this type of cancer due to cerebral metastases, spinal cord compression or even complications from treatment (either chemotherapy or immunotherapy). Paraneoplastic neurological syndromes and hypercoagulability syndrome are two complicated conditions which connect small cell carcinoma and nervous system. In this article, an extensive reference is made to the two latter situations through the description of two incidents: one with subacute cerebellar degeneration and one with hypercoagulable syndrome and multiple ischemic strokes in patients with SCLC.