July - September 2018: 
Volume 31, Issue 3

Click on the image to download the Issue in PDF format.


Pneumon 2018, 31(3):147-150, Editorial
Depression, antidepressants and pulmonary embolism
Authors Information

First Academic Department of Pneumonology, Interstitial Lung Diseases Unit, Hospital for Diseases of the Chest, “Sotiria”, Medical School, National and Kapodistrian University of Athens, Athens, Greece


1. Konstantinides SV, Torbicki A, Agnelli G, et al. 2014 ESC guidelines on the diagnosis and management of acute pulmonary embolism. European Heart Journal 2014; 35: 3033-69, 3069a-3069k.

2. Tzouvelekis A, Kouliatsis G, Oikonomou A, et al. Post-intubation pulmonary embolism and tracheal stenosis: a case report and review of the literature. Respir Med 2008; 102:1208-12.

3. Enga KF, Braekkan SK, Hansen-Krone IJ, Hansen JB. Emotional states and future risk of venous thromboembolism: the Tromso Study. Thrombosis and Haemostasis 2012; 107:485-93.

4. Austin AW, Wissmann T, von Kanel R. Stress and hemostasis: an update. Seminars in Thrombosis and Hemostasis 2013; 39:902-12.

5. Lee CW, Liao CH, Lin CL, Liang JA, Sung FC, Kao CH. Depression and risk of venous thromboembolism: a population-based retrospective cohort study. Psychosomatic Medicine 2015; 77:591-8.

6. Wu CS, Chang CM, Chen CY, et al. Association between antidepressants and venous thromboembolism in Taiwan. Journal of Clinical Psychopharmacology 2013; 33:31-7.

7. Parkin L, Balkwill A, Sweetland S, Reeves GK, Green J, Beral V. Antidepressants, Depression, and Venous Thromboembolism Risk: Large Prospective Study of UK Women. Journal of the American Heart Association 2017; 6.

8. Jick SS, Li L. Antidepressant drug use and risk of venous thromboembolism. Pharmacotherapy 2008; 28:144-50.

9. Ray JG, Mamdani MM, Yeo EL. Antipsychotic and antidepressant drug use in the elderly and the risk of venous thromboembolism. Thrombosis and Haemostasis 2002; 88:205-

10. Lacut K, Le Gal G, Couturaud F, et al. Association between antipsychotic drugs, antidepressant drugs and venous thromboembolism: results from the EDITH case-control study. Fundamental & Clinical Pharmacology 2007; 21:643-50.

11. Kunutsor SK, Seidu S, Khunti K. Depression, antidepressant use, and risk of venous thromboembolism: systematic review and meta-analysis of published observational evidence. Annals of Medicine 2018: pp. 1-17.

12. Parkin L, Skegg DC, Herbison GP, Paul C. Psychotropic drugs and fatal pulmonary embolism. Pharmacoepidemiology and Drug Safety 2003; 12:647-52.

13. Branchford BR. Venous Thromboembolism Risk With Antidepressants: Driven by Disease or Drugs? Journal of the American Heart Association 2017; 6.

14. Adelborg K, Sundboll J, Videbech P, Grove EL. The Risk of Thromboembolism in Users of Antidepressants and Antipsychotics. Advances in Experimental Medicine and Biology 2017; 906:351-61.

15. Van Neste EG, Verbruggen W, Leysen M. Deep venous thrombosis and pulmonary embolism in psychiatric settings. The European Journal of Psychiatry 2009; 23:19-30.

16. Anderson FA, Jr., Spencer FA. Risk factors for venous thromboembolism. Circulation 2003; 107:I9-16.

17. Burrows GD, Kremer CM. Mirtazapine: clinical advantages in the treatment of depression. Journal of Clinical Psychopharmacology 1997; 17(Suppl 1):34s-39s.

18. von Kanel R, Margani A, Stauber S, et al. Depressive symptoms as a novel risk factor for recurrent venous thromboembolism: a longitudinal observational study in patients referred for thrombophilia investigation. PloS one 2015; 10:e0125858.

19. Lopez-Vilchez I, Serra-Millas M, Navarro V, et al. Prothrombotic platelet phenotype in major depression: downregulation by antidepressant treatment. Journal of Affective Disorders 2014; 159:39-45.

20. Williams MS, Rogers HL, Wang NY, Ziegelstein RC. Do platelet-derived microparticles play a role in depression, inflammation, and acute coronary syndrome? Psychosomatics 2014; 55:252-60.

21. Ignatowski M, Sidhu S, Rueve M. Pulmonary embolism as a complication of major depressive disorder with catatonic features: a case report. Psychiatry (Edgmont (Pa: Township)) 2007; 4:51-6.

22. Chung KH, Chiou HY, Chen YH. Associations between serum homocysteine levels and anxiety and depression among children and adolescents in Taiwan. Scientific Reports 2017; 7:8330.

23. Folstein M, Liu T, Peter I, et al. The homocysteine hypothesis of depression. The American Journal of Psychiatry 2007; 164:861-7.

24. Narayan SK, Verman A, Kattimani S, Ananthanarayanan PH, Adithan C. Plasma homocysteine levels in depression and schizophrenia in South Indian Tamilian population. Indian journal of psychiatry 2014; 56:46-53.

25. Orr MW, Boullin DJ. The relationship between changes in 5-HT induced platelet aggregation and clinical state in patients treated with fluphenazine. British Journal of Clinical Pharmacology 1976; 3:925-8.

26. Zornberg GL, Jick H. Antipsychotic drug use and risk of first-time idiopathic venous thromboembolism: a case-control study. Lancet (London, England) 2000; 356:1219-23.

27. Keles E, Ulasli SS, Basaran NC, Babaoglu E, Koksal D. Acute massive pulmonary embolism associated with olanzapine. The American Journal of Emergency Medicine 2017; 35:582.e1585-1582.e1587.

28. Wang Q, Guan L, Li RM, Zhao B. Pulmonary thromboembolism associated with olanzapine treatment. Chinese Medical Journal 2015; 128:419-20.

29. Skop BP, Brown TM. Potential vascular and bleeding complications of treatment with selective serotonin reuptake inhibitors. Psychosomatics 1996; 37:12-6.

30. Zhou Haixia TY, Yan Yu, Yi Qun, Du Xinmiao, Liang Zongan. Antidepressant Drugs and Risk of Venous Thromboembolism: A Case Report and Literature Review. Klinik Psikofarmakoloji Bülteni-Bulletin of Clinical Psychopharmacology 2011; 21:237-41.

31. Tzouvelekis A, Kourtidou S, Bouros E, et al. Impact of depression on patients with Idiopathic Pulmonary Fibrosis. American Journal of Respiratory and Critical Care Medicine 2017;195:A1138

32. Richards D. Prevalence and clinical course of depression: a review. Clinical Psychology Review 2011; 31:1117-25.